Designing a protein is cheap. Finding out if a cell can make it isn't.
Sequences can be generated faster than any lab can test them, but each one still has to be built and validated at the bench, so choosing which to make is a guess.
For all the progress in protein design, one problem remains unsolved: how well will a new sequence express? The answer is hidden in a cellular supply chain no one could measure — until now.
Sequences can be generated faster than any lab can test them, but each one still has to be built and validated at the bench, so choosing which to make is a guess.
A cell can make protein only as fast as it can supply the parts the protein needs. If demand outruns supply, production stalls and yield drops — with no outward sign of why.
Andon reads the cellular supply chain directly as proteins are being made, connecting the demand a sequence puts on the supply to how well it expresses.
Every protein measured sharpens the next prediction, letting researchers design for manufacturability from the start instead of discovering it through trial and error.